Pentoxifylline, sold under the brand name Trental is typically used for vascular disease to increase blood flow due to its effect in reducing blood viscosity.  However, there is a gene called c-Rel that is important to maintain the function of regulatory cells such as Tregs and MDSC.  As I have discussed, the immune system has two sides, one that is regulatory, which has been tricked by cancer to protect it.  There is the other side that can attack cancer.

Our goal is to tip the balance in favor of attacking cancer.   In a study published by Grinberg-Bleyer, et al in Cell, Sept 7, 2017, titled “NF-kB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer” they describe how blocking c-Rel can reduce the regulatory function of Tregs.  In addition, Li, et al published in Nature Cancer, May 18, 2020, an article titled “c-Rel is a Myeloid Checkpoint for Cancer Immunotherapy” which discusses MDSC.

Side Effects of Immunotherapy

When it comes to managing the side effects of immunotherapy it is important to be very detailed with observing the symptoms as they can be autoimmune related. With any side effect, if it starts to escalate into something more severe, it is important for the patient to notify the doctor immediately. Below are a couple of the most common side effects or autoimmune-related events experienced by patients who undergo immune checkpoint therapy:

-Skin rash, itching
-Dry mouth

Cryoablation for Breast Cancer

Cancer is a frightening word for anyone to hear. When it comes to breast cancer, many women feel an especially strong fear. Fortunately, treatments are improving every day and there are now a variety of treatment options available. One such option is Breast Cancer Cryoablation. This article will discuss what Cryoablation is, the benefits of this treatment method, and how it may be right for you.
Cryoablation is a surgical procedure that uses extreme cold to destroy breast cancer cells. This minimally invasive treatment is an alternative to traditional surgery for women with early-stage breast cancer. Cryoablation can be used to treat tumors that are too small to remove with traditional surgery or when traditional surgery is not possible.