Performing microdosed intratumoral chemotherapy since 2015
2-in-1
Chemotherapy and immunotherapy through the same needle
In plain terms
What this procedure is, without the jargon.
Most chemotherapy is given through an IV at the highest dose the body can tolerate — which causes the well-known side effects. This procedure, which we call the Precision Strike, flips that: a microdosed amount of chemotherapy, often a tenth to a hundredth of the usual dose, is injected directly into the tumor. The tumor gets a high concentration while the rest of the body is largely spared.
The chemotherapy kills cancer cells in a way that releases their “fingerprints” — immunogenic cell death — and in the same session we inject intratumoral immunotherapy to amplify the immune system’s recognition of those signals.
It is aimed at solid tumors that respond to chemotherapy but where whole-body toxicity limits the dose, or where standard IV chemotherapy isn’t a good option. Because it treats only the injected tumor, for widespread disease it complements rather than replaces standard chemotherapy — while adding an immune-engagement step that IV chemotherapy alone doesn’t provide.
Precision strike: a fraction of the usual dose, placed inside the tumor instead of the whole body.
The treated tumor teaches your immune system to recognize the cancer body-wide.
How it works
How the procedure runs.
Part 1
Image-guided microdosed chemotherapy
CT or ultrasound guidance to the tumor target — the same access as AblationVax. Selected cytotoxic agents are delivered at dramatically reduced doses, typically a tenth to a hundredth of the IV maximum tolerated dose, achieving high local concentration without systemic toxicity. Agents are chosen on tumor histology, immune microenvironment and prior chemotherapy exposure.
Part 2
Intratumoral immunotherapy co-delivery
Multi-agent immune cocktails are injected in the same session — checkpoint inhibitors, TLR agonists and costimulatory agonists — so the immune system is amplified exactly where the chemotherapy just created the danger signal. One hour, same-day recovery.
What makes it different
What makes this different.
Standard approaches
Our approach
IV chemotherapy at maximum tolerated dose — systemic toxicity accepted for tumor effect.
Microdosed and placed in the tumor— high local concentration, the rest of the body largely spared.
TACE for liver or intravesical infusion for bladder — organ-specific delivery.
Direct injection into solid tumorsacross sites, paired with immunotherapy through the same needle.
Chemotherapy mechanism only.
Immunogenic cell death plus immune amplificationat the target.
Why microdosing works here.
Concentration without the toll
Placing the drug inside the tumor achieves local levels an IV cannot reach at any tolerable dose — without the whole-body exposure that limits chemotherapy.
Chemotherapy as an immune trigger
The right cytotoxic agents kill cells in a way that releases antigens and stress signals, doing the job ablation does when ablation isn’t suitable.
Two mechanisms, one needle
The chemotherapy creates the danger signal; the immunotherapy injected alongside it amplifies immune recognition of what was just released.
Is this right for you
When this procedure is right.
This procedure is considered for:
✓Solid tumors that respond to chemotherapy but where systemic toxicity limits the dose
✓Patients seeking a chemotherapy effect without whole-body IV exposure
✓Tumors where chemotherapy-induced immunogenic cell death can be combined with immune amplification
✓Cases where standard IV chemotherapy is ruled out by performance status or organ dysfunction
“Microdosed chemotherapy injected directly into the tumor delivers precise cytotoxicity, targeted anti-angiogenesis and immunomodulation — with limited off-target toxicity.”
— From the WCI intratumoral toolkit, precision strike category
Track record
Pioneering intratumoral chemotherapy.
2015
Microdosed intratumoral chemotherapy
Paired with multi-agent intratumoral immunotherapy across solid tumor types.
Now
Ablation plus microdose plus immunotherapy
All three combined in one session where the tumor biology calls for it.
Ready to move forward?
There is more ahead. Take the next step with confidence.
Complimentary evaluation.
Dr. Williams’ team will personally review your case and imaging — no cost, no obligation.
