This certainly may apply to many cancers, as unfortunately, most are immunologically “cold,” which is why the current FDA approved immunotherapies fail in the majority of cases. There are numerous techniques to turn “cold” tumors to “hot.” Among these are injection into a tumor TLR agonist, STING agonist, CD40 agonist, and Oncopore peptides, to name a few. This article discusses using ultrasound to control temperature. The surprising aspect was it was not necessarily heating things up, like hyperthermia, but keeping the temperature stable. A very interesting and unexpected conclusion.
There is also a nice animation explaining the immune response to cancer and how cancer can evade the immune system.