Pulsed Electrical Field (PEF)
Pulsed Electrical Field (PEF) is a promising technique for the treatment of cancer that uses short pulses of high-voltage electricity to selectively target cancer cells while leaving
healthy cells unharmed. PEF has been shown to be effective in a number of preclinical studies and is currently being studied in clinical trials for the treatment of various types of cancer.
During the PEF treatment, electrodes are placed on the surface of the skin or inserted into the tumor. Short pulses of high-voltage electricity are then delivered to the tumor, creating an electric field that causes pores to form in the cell membranes of cancer cells.
These pores disrupt the cell membrane, leading to cell death.
One advantage of PEF over traditional cancer treatments such as chemotherapy and radiation therapy is that it is non-invasive and does not cause the same level of side effects. PEF has been shown to be well-tolerated in clinical trials, with few adverse effects reported.
PEF is also highly selective, targeting cancer cells while leaving healthy cells unharmed.
This means that PEF has the potential to be used in combination with other cancer treatments, such as chemotherapy and radiation therapy, to enhance their effectiveness and reduce side effects.
While PEF shows great promise as a cancer treatment, further research is needed to fully understand its potential applications and to optimize its use. Clinical trials are currently
underway to evaluate the safety and effectiveness of PEF in the treatment of various types of cancer.
Jason R. Williams, MD, DABR