Williams Cancer Institute

NATURAL SUBSTANCES AND SUPPLEMENTS TO IMPROVE THE IMMUNE RESPONSE TO CANCER PART 2

EGCG EPIGALOCATECHINGALATE

EGCG (epigallocatechygallate) EGCG is a polyphenol usually extracted from green tea. It is a supplement that is frequently used in the treatment of cancer, liver damage has been reported in high doses. Therefore, EGCG should be used with precaution, its use should be discussed with your doctor before consuming or participating in any of these other therapies. Studies have also suggested that the combination of EGCG with epigallocatechingallate or green tea along with curcumin can reduce TFC-B. Additionally, several studies have shown that EGCG can inhibit cancer stem cells.

SULFORAPHAN

Sulforaphane is obtained from cruciferous vegetables such as broccoli. It is necessary to have an enzymatic production of sulforaphane, which is generated when myrosinase converts glucoraphanin into sulforaphane. It is important to obtain this supplement in activated form, sulforaphane can cause a reduction in CSDMs, which helps the immune response to cancer.

The authors, Liang, et al. published a study in AdvBiolRegul, January 2019, discussing how sulforaphane can be a “double-edged sword” when it comes immunotherapy to cancer cells -T human, which can inhibit its activation and tumor. In general, it is thought that the benefits may outweigh the disadvantages, but we certainly need more studies.

POLIDATINE

Polydatin is a precursor that inhibits G6PD, a major pathway for glucose metabolism, polydatin suppressed cancer proliferation and metastasis. Although there is no direct relationship with the way this may affect the immune response. Also, glucose metabolism generates substantial lactic acid production immune checkpoint metabolic. Moreover, there is evidence that polydatin can reduce the Wnt/beta-catenin signaling pathway, which could theoretically lead to increased infiltration of immune cells into the microenvironment tumor

BETA-GLUCAN

Beta-glucans, also known as β-glucans, are polysaccharides that come from the cell walls of oats, barley, mushrooms, yeast, bacteria, and fungi. They bind to immune receptors and can attract immune cells to the tumor environment. Depending on where they are derived, B-glucans can have different effects, it remains unclear which, if any, source of B-glucans is superior.

Theoretically, B-glucans from oats/barley may have an advantage, but this has not yet been fully proven. Regardless of the source, all types of B-glycans appear to have immunostimulatory, having the ability to reduce regulatory cells and increase immunostimulatory cytokines, which may help “raise the temperature” in the tumor microenvironment.

Finally, a cold tumor microenvironment is one of the major reasons for immunotherapy failure, β-glycans have the potential to stimulate the response to immunotherapy.

References:

Williams, J. (2019, 15th October) The Immunotherapy Revolution. Pg 132-134

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