Injecting small amounts of two immune-stimulating agents into tumors in mice has shown to be able to eliminate the tumor, other untreated metastases and all traces of the same cancer according to a study by researchers at the Stanford University School of Medicine.
The Stanford researchers found activating T cells in tumors eliminated even distant metastases in mice, the technique been tested on mice with lymphoma, breast, colon and melanoma tumors. An interesting effect of activating the T cells not only impacts on the specific tumor. The activated T cells then leave the original tumor and can find and destroy other identical tumors in other areas throughout the body.
Professor of oncology,Ronald Levy, MD said: When we use these two agents together, we see the elimination of tumors all over the body. This approach bypasses the need to identify tumor-specific immune targets and doesn’t require wholesale activation of the immune system or customization of a patient’s immune cells.
Research continues with this finding and testing with clinical trials has been proposed. Lymphoma patients for a clinical trail is being planned to test the technique. The current clinical trial is expected to recruit about 15 patients.
Read the complete Stanford Medicine article.