Williams Cancer Institute

Fisetin: An Anticancer Perspective

Introduction: Fisetin is a natural flavonoid found in various fruits and vegetables, known for its potential health benefits. This article delves into the promising anticancer properties of fisetin, shedding light on its mechanisms of action and potential applications in cancer treatment.

The Role of Fisetin in Cancer Prevention:

  1. Antioxidant Properties: Fisetin acts as a potent antioxidant, combating oxidative stress and reducing DNA damage, which is a key factor in cancer development.
  2. Anti-Inflammatory Effects: Chronic inflammation is associated with cancer progression. Fisetin exhibits anti-inflammatory properties, potentially inhibiting cancer-related inflammation.
  3. Apoptosis Induction: Fisetin has shown the ability to induce apoptosis, or programmed cell death, in cancer cells. This is a crucial mechanism for preventing cancer cell proliferation.

Fisetin and Cancer Types:

  1. Breast Cancer: Research suggests that fisetin may inhibit the growth of breast cancer cells by interfering with specific signaling pathways involved in cancer progression.
  2. Prostate Cancer: Fisetin has demonstrated potential in suppressing prostate cancer growth by modulating cell cycle regulators and inducing apoptosis.
  3. Colorectal Cancer: Studies indicate that fisetin may inhibit colorectal cancer cell proliferation and induce cell cycle arrest and apoptosis.

Combination Therapy: Fisetin’s potential as an adjuvant therapy alongside conventional cancer treatments like chemotherapy is being explored. It may enhance the efficacy of these treatments while reducing their side effects.

Conclusion: Fisetin, a naturally occurring flavonoid, holds promise as an anticancer agent. Its antioxidant, anti-inflammatory, and apoptosis-inducing properties make it a subject of interest in cancer research. While further studies are needed to establish its clinical applications, fisetin offers a potential avenue for cancer prevention and treatment.

Reference: Muhammad Imran, Farhan Saeed, Syed Amir Gilani, Mohammad Ali Shariati, Ali Imran, Muhammad Afzaal, Muhammad Atif, Tabussam Tufail, Faqir M. Anjum, 25 Nov 2020, Fisetin: An anticancer perspective, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802565

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