Doxorubicin is a chemotherapy agent that works by interfering with DNA replication. It originated from soil bacteria and is considered an anti-tumor antibiotic. It generally has a bad reputation for its side effects. Besides bone marrowsuppression and hair loss, toxicity to the heart can be a major problem. It is red in color and often is called “Red Death.”On the positive side, it does seem to have some immune- stimulating aspects by killing tumors in a manner that may attract the immune system. At this time there is not much data on the combination of Doxorubicin with immunotherapy, but as with other chemo drugs, we would expect a low dose to stimulate the immune response and have reduced side effects.
Reference: Jason R. Williams, 15 Oct 2019, The Immunotherapy Revolution: The Best New Hope For Saving Cancer Patients’ Lives, https://williamscancerinstitute.com/the-immunotherapy-revolution