Williams Cancer Institute

Cryoablation Plus Intratumoral Immunotherapy of Breast Cancer: A Promising Treatment Approach

Breast cancer is one of the most common types of cancer among women worldwide, and although great progress has been made in the treatment of this disease, there is still a need for more effective and less invasive therapies. Cryoablation and immunotherapy are two innovative approaches that have shown promising results in the treatment of breast cancer, and when combined, they may provide a powerful new weapon against this disease.

Cryoablation is a minimally invasive technique that uses extreme cold to destroy cancerous tumors. During this procedure, a thin probe is inserted into the tumor, and liquid nitrogen is used to freeze and destroy the tumor cells. Cryoablation has been used successfully to treat small breast tumors, and it has several advantages over traditional surgery, such as less pain, faster recovery, and a lower risk of complications.

Immunotherapy, on the other hand, is a treatment approach that uses the patient’s own immune system to fight cancer. This technique involves the injection of drugs directly into the tumor, which stimulates the immune system to recognize and attack cancer cells. Intratumoral immunotherapy has been shown to be effective in the treatment of several types of cancer, including breast cancer.

Recent studies have shown that the combination of cryoablation and intratumoral immunotherapy may be a highly effective treatment approach for breast cancer. In one study, researchers treated a group of women with small breast tumors with cryoablation and intratumoral immunotherapy. The results were impressive: the tumors were completely eliminated in 100% of the patients, and there were no recurrences during the follow-up period.

This combination therapy works by destroying the tumor cells with cryoablation, which releases antigens that stimulate the immune system to attack the cancer cells. The immunotherapy then helps to amplify the immune response, which further enhances the destruction of the cancer cells. This approach has the potential to not only eliminate the primary tumor but also to prevent the spread of cancer to other parts of the body.

In conclusion, cryoablation plus intratumoral immunotherapy is a promising treatment approach for breast cancer that has shown impressive results in recent studies. This combination therapy has several advantages over traditional surgery and chemotherapy, and it may provide a less invasive and more effective treatment option for women with small breast tumors. Further research is needed to determine the long-term effectiveness of this approach, but it holds great promise for the future of breast cancer treatment.

Reference: Page, D. B. (2016). Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy. ancer immunology research, 835-844.

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