Camu Camu is an Amazonian fruit rich in polyphenols, compounds found in plants known for their antioxidant and health benefits with protective effects against obesity and diabetes. Recently studies have been made discussing its effect on cancer.
One of the polyphenols found in Camu Camu is Castalagin; this polyphenol acts as a prebiotic, modifies gut microbiome, and improves immunotherapy response, according to a Canadian Study *. It has de prebiotic potential to enrich Akkermansia muciniphila, a bacterium shown to alleviate metabolic disorders and improve Immune-checkpoints inhibitors.
Oral supplementation with Castalagin in mice shifted gut microbial composition, which translated into antitumor activity and stronger anti-PD1 (programmed death cell protein 1) response.
With this background, new clinical studies are being made to prove the efficacy of Camu Camu’s castalagin anti-cancer effect in patients with non-small cell lung cancer and metastatic melanoma.
* University of Montreal Hospital Research Centre (CRCHUM). “Cancer treatment: A berry from Brazil helps out.” ScienceDaily. ScienceDaily, 2 February 2022.